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Additionally, RGS4 is found to co-localize and directly associate with GABA B receptors immunoprecipitated from the brain ( B receptors, G o subunits, RGS4 proteins, and GIRK2 channels, implying a rapid and specific activation of GIRK2 channels by these modulators ( The overall impact of endogenous RGS proteins on GIRK channel gating suggests that individual RGS knockouts only influence a minor subset of the total RGS influence on GIRK channel gating

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